Guo Zhixue1,
Ge Changqing1,
Han Bing1,
Qie Zengwang1,
Kang Yanjie1,
Liu Bo1,
Zhu Ya1,
Wang Weihong1,
Tian Liqing1,
Feng Xin1,
Ma Xiaoyong2 
For correspondence:- Ma Xiaoyong Email: pnbcg7@163.com
Accepted: 27 February 2018 Published: 31 March 2018
Citation: Zhixue G, Changqing G, Bing H, Zengwang Q, Yanjie K, Bo L, et al. Effects of parenteral nutrition of `9;-3 polyunsaturated fatty acid, arginine and glutamine on cellular immune status of patients following liver cancer surgery. Trop J Pharm Res 2018; 17(3):507-511 doi: 10.4314/tjpr.v17i3.17
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To study the effects of parenteral nutrition (TPN), ω-3 polyunsaturated fatty acid (PUFA), L-arginine (Arg), and glutamine on cellular immunity of patients who have done the liver cancer (LC) surgery.
Methods: Seventy-five (75) LC patients were randomly divided into 5 groups (A - E; 15 cases each), group A, B, C, D and E, in which patients were treated with TPN, TPN + fish oil, TPN + Arg, TPN + glutamine, and TPN + ω-3 PUFA + Arg + glutamine, respectively. Before and after surgery, CD3 +, CD4 + and CD8 + were measured by antibody-sensitized erythrocyte rosette test, and IL-6, IL-10 and TNF-a were assayed with double-antibody sandwich enzyme-linked immunoassay (DAS-ELISA). IgA and IgM were measured nephelometrically.
Results: The levels of CD3 +, CD4 + and CD8 + in group A showed no obvious change after surgery (p > 0.05). However, CD3 + and CD4 + increased in groups B, C and D, while CD8 + decreased in group E (p < 0.05). IL-6 in group E was lower than that in any of the other four groups (p < 0.05). IL-10 in group A was lower than that in groups B, C and D, but lower than in group E (p < 0.05). The levels of TNF-a in groups B and C were lower than those in group A, but higher than that in group E (p < 0.05) but lower than in group D. IgA in group E was higher than in the other groups (p < 0.05), while IgM level in group E was lower than in groups A, B and C (p < 0.05).
Conclusion: Immunosuppressive status and cellular immunity of patients after liver cancer surgery may be improved by a combination therapy of TPN, ω-3 PUFAs, Arg and glutamine
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